What is NFkB inhibitor?
NFkB1 (NFkB p50) and NFkB2 (NFkB p52) are class I members of the Rel/NFkB family of transcription factors that also includes RelA, c-Rel and RelB. Rel/NFkB members regulate expression of genes that participate in immune, apoptotic and oncogenic processes.
What does IKba do?
The best-studied and major IkB protein is IkBa. The IkBs bind to NF-kB dimers and sterically block the function of their NLSs, thereby causing their cytoplasmic retention. In order to get NF-kB into the nucleus, its site of action, the cytoplasmic NF-kB:IkB complex needs to be disrupted.
What does IKBA stand for?
IKBA
| Acronym | Definition |
|---|---|
| IKBA | Ike Kligerman Barkley Architects |
| IKBA | I Know B*gger All |
| IKBA | Inhibitor of Kappa Light Chain Gene Enhancer in B Cells, Alpha I-Kappa-B-Alpha |
| IKBA | Italian-Korean Business Association (South Korea and Italy) |
What does the NFKB pathway do?
Nuclear factor kappa B (NF-κB) is an ancient protein transcription factor (Salminen et al., 2008) and considered a regulator of innate immunity (Baltimore, 2009). The NF-κB signaling pathway links pathogenic signals and cellular danger signals thus organizing cellular resistance to invading pathogens.
What is I kappa B alpha?
IκBα (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha) is one member of a family of cellular proteins that function to inhibit the NF-κB transcription factor.
What is NF KB?
NF-κB plays a key role in regulating the immune response to infection. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory.
What is Ikbalpha?
IkB-alpha a regulatory protein that inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals.
What does NF-kB bind to?
Activated NF-kB (p65) translocates from the cytoplasm to the nucleus, where it physically binds to myocardin, preventing the formation of myocardin/SRF/CArG ternary complex, and thus inhibiting SRF-regulated gene expression. This repression ultimately results in increased cell proliferation.
What is NF-κB signaling pathway?
How does IκBα inhibit NF-κB?
IκBα inhibits NF-κB by masking the nuclear localization signals (NLS) of NF-κB proteins and keeping them sequestered in an inactive state in the cytoplasm. In addition, IκBα blocks the ability of NF-κB transcription factors to bind to DNA, which is required for NF-κB’s proper functioning.
What does IκBα stand for?
IκBα (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha) is one member of a family of cellular proteins that function to inhibit the NF-κB transcription factor. IκBα inhibits NF-κB by masking the nuclear localization signals (NLS) of NF-κB proteins and keeping them sequestered in an inactive state in the cytoplasm.
What is the role of NF-kappaB and IkappaB in inflammatory diseases?
Because deregulation of NF-kappaB and IkappaB phosphorylations is a hallmark of chronic inflammatory diseases and cancer, newly designed drugs targeting these constitutively activated signalling pathways represent promising therapeutic tools.
Is IkappaB Alpha a target for mitogen-activated 90 kDa ribosomal s6 kinase?
“IkappaB alpha is a target for the mitogen-activated 90 kDa ribosomal S6 kinase”. EMBO J. 16 (11): 3133–44. doi: 10.1093/emboj/16.11.3133.