What is an abnormal hemoglobin?
If levels of HgbA or HgbF are too high or too low, it can indicate certain types of anemia. Abnormal types of hemoglobin include: Hemoglobin (Hgb) S. This type of hemoglobin is found in sickle cell disease. Sickle cell disease is an inherited disorder that causes the body to make stiff, sickle-shaped red blood cells.
What is the mutation in hemoglobin?
The mutation that causes hemoglobin S changes a single protein building block (amino acid) in beta-globin. Specifically, the amino acid glutamic acid is replaced with the amino acid valine at position 6 in beta-globin, written as Glu6Val or E6V.
What is a variant in your blood?
Hemoglobin variant trait (AV) is an inherited condition which affects the hemoglobin in your red blood cells. • Hemoglobin is a protein in red blood cells. The job of hemoglobin is to. carry oxygen through the body. • Each person inherits two hemoglobin genes – one from each parent.
What is Hb variant test?
What is Hemoglobin variant analysis – HPLC test? Hemoglobin variant analysis – HPLC test is used to diagnose hemoglobin variants, thalassemia, and to monitor carrier status.
What diseases are associated with hemoglobin?
Hemoglobin Sickle Cell Anemia. Hemoglobin Sickle C Disease. Hemoglobin S/Beta + Thalassemia. Hemoglobin C/Beta + Thalassemia.
What are the 5 hemoglobin variants?
- Beta Thalassemia.
- Embryonic Hemoglobin.
- Sickle-Cell Disease.
- Blood Cell.
- Hemoglobin Beta Chain.
What is a variant trait?
What is hemoglobin variant trait? The normal, and most common, type of hemoglobin is called hemoglobin A. Hemoglobin variant trait is when a baby inherited one gene for hemoglobin A from one parent and one gene for a hemoglobin variant from the other parent. People with hemoglobin variant trait are not sick.
What does low hemoglobin F mean?
Higher-than-normal amounts of both hemoglobin A2 and hemoglobin F may mean a mild form of thalassemia is present. A very low level of hemoglobin A and a high level of hemoglobin F may mean a more severe form of thalassemia.
What are the 4 types of hemoglobin?
There is more than one hemoglobin gene: in humans, hemoglobin A (the main form of hemoglobin present in adult) is coded for by the genes, HBA1, HBA2, and HBB. The hemoglobin subunit alpha 1 and alpha 2 are coded by the genes HBA1 and HBA2, respectively, which are both on chromosome 16 and are close to each other.
What does low hemoglobin cause?
Low hemoglobin that’s caused by low iron levels is known as iron deficiency anemia. Not getting enough iron in your diet is the most common cause of low hemoglobin. Symptoms of low hemoglobin include headaches, fatigue, and pale skin. Treatments for low hemoglobin include iron supplements, iron therapy, and surgery.