What is cyclodextrin used for?
In the pharmaceutical industry, cyclodextrins have mainly been used as complexing agents to increase the aqueous solubility of active substances poorly soluble in water, in order to increase their bioavailability and to improve stability.
What drugs use cyclodextrin?
Introduction
| Drug/cyclodextrin | Trade name | Formulation |
|---|---|---|
| 2-Hydroxypropyl-β-cyclodextrin (HPβCD) | ||
| Cisapride | Propulsid | Suppository |
| Indometacin | Indocid | Eye drop solution |
| Itraconazole | Sporanox | Oral and intravenous solution |
Is beta cyclodextrin harmful?
Most of the hydrophilic derivatives of natural cyclodextrins like 2-hydroxypropyl-β-cyclodextrin and sulphobutylether-β-cyclodextrin are considered safe for parenteral administration. Higher dose of cyclodextrins may be harmful.
What is another name for cyclodextrin?
beta-CYCLODEXTRIN
| PubChem CID | 444041 |
|---|---|
| Structure | Find Similar Structures |
| Chemical Safety | Laboratory Chemical Safety Summary (LCSS) Datasheet |
| Molecular Formula | (C6H10O5)7 or C42H70O35 |
| Synonyms | beta-CYCLODEXTRIN Betadex Cycloheptaamylose Cyclomaltoheptaose Cycloheptaglucan More… |
Where can I get cyclodextrin?
Cyclodextrins can be found in nature. Some bacteria (e.g. Bacillus macerans) produce CDs from starch by enzymatic process for their energy storage. This process is mimicked by the industry using cyclodextrin glycosyltransferase enzyme and starch (corn, potato, manioc, etc) as raw material.
Are cyclodextrin safe?
Concentrations up to 0.1% of α-, β-, and γ-cyclodextrins are considered safe. Studies on antigenicity, mutagenicity, and topical irritation have proven that HP-β-CD is as safe as materials currently being used in perfumes and cosmetics.
How much beta cyclodextrin should I take?
A maximal level of β-cyclodextrin of 5 mg kg-1 per day in foods is recommended by the Joint FAO/WHO Expert Committee on Food Additives (JECFA). β-Cyclodextrin is ‘generally recognized as safe’ (GRAS) in the United States and a ‘natural product’ in Japan.
What is Betadex sulfobutyl ether sodium?
Betadex Sulfobutyl Ether Sodium (BSES) is a cyclodextrin that is used as a drug delivery solution. In a USP monograph the purity analysis requirements of this substance is described. The ALEXYS Analyzer for BSES meets these requirements.
How many cyclodextrins are there?
three
Cyclodextrins are available in three forms such as α-cyclodextrin, β-cyclodextrin, and γ-cyclodextrin, which comprised of six, seven, and eight α-1,4-glycosidic bonds (as shown in Figs.