What are the inclusion bodies of Chlamydia trachomatis?

What are the inclusion bodies of Chlamydia trachomatis?

trachomatis attaches to a new host cell as a small spore-like form called the elementary body. The elementary body enters the host cell, surrounded by a host vacuole, called an inclusion. Within the inclusion, C. trachomatis transforms into a larger, more metabolically active form called the reticulate body.

What is chlamydial inclusion?

Chlamydia is an obligate intracellular pathogen that develops in the host cell in a vacuole termed the chlamydial inclusion. The prevailing concept of the chlamydial inclusion is of a parasitophorous vacuole.

What are the differences between chlamydial elementary bodies and reticulate bodies?

Elementary bodies are metabolically inactive. They infect the host when the cell ingests them (receptor-mediated endocytosis). Once inside the cell, the elementary bodies differentiate into reticulate bodies, which are metabolically active but noninfectious.

Does Chlamydia form inclusion bodies inside cells?

All chlamydiae share a developmental cycle in which they alternate between the extracellular, infectious elementary body and the intracellular, non-infectious reticulate body7 (FIG. 1). Elementary bodies enter mucosal cells and differentiate into reticulate bodies in a membrane bound compartment — the inclusion.

Is Chlamydia trachomatis an atypical bacteria?

The atypical bacterial pathogens—Mycoplasma pneumoniae, Chlamydophila pneumoniae, and Chlamydia trachomatis—are recognized as respiratory pathogens. They are all small bacteria and cannot be detected using routine culturing methods.

Is Chlamydia and Chlamydia trachomatis the same thing?

Chlamydia is a common sexually transmitted disease. It is caused by bacteria called Chlamydia trachomatis. It can infect both men and women. Women can get chlamydia in the cervix, rectum, or throat.

What are TRIC agents?

TRIC is derived from words Trachoma and Inclusion Conjunctivitis. Both of these ophthalmic diseases are produced by a bacterium Chlamydia trachomatis. Serotypes of C. trachomatis A to K are together called TRIC agents.

How is chlamydial conjunctivitis spread?

Chlamydial conjunctivitis is a sexually transmitted disease and occurs most commonly in sexually active young adults. Women are more susceptible than men. The disease is usually transmitted through hand-to-eye spread of infected genital secretions.

What is the natural habitat of Chlamydia trachomatis?

In ruminants, the intestinal epithelium appears to be an important natural habitat for Chlamydia. Persistent intestinal infections are common in cattle, sheep, and goats. The organism may be shed in feces, nasal, ocular, or vulvar discharges or in uterine fluids, placenta, or urine.

What is the pathogenesis of Chlamydia trachomatis?

Disease pathogenesis due to Chlamydia trachomatis is a complicated process that involves: (1) exposure to the organism and infectivity; (2) survival within the host cell; (3) virulence associated with specific strain types; (4) innate and acquired immunity, and (5) host genetic susceptibility to infection and disease.

How does Chlamydia trachomatis enter a target cell?

Chlamydiae initiate their intracellular life cycle by invading cells in the form of elementary bodies (EBs) (1). EBs rapidly differentiate into reticulate bodies (RBs) that are metabolically active and proliferate inside cytoplasmic parasitophorous vacuoles termed inclusions (1).

Is chlamydia a bacilli or cocci?

(bacterium) Typical representatives: Staphylococci are the most common cluster-forming cocci. Chlamydia trachomatis is an intracellular, Gram-negative bacterium in the Chlamydiaceae family.

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