What are examples of acetylcholinesterase inhibitors?

What are examples of acetylcholinesterase inhibitors?


  • Physostigmine.
  • Neostigmine.
  • Pyridostigmine.
  • Ambenonium.
  • Demecarium.
  • Rivastigmine.

Which drug is choline esterase inhibitor?

List of Cholinesterase inhibitors:

Drug Name Avg. Rating Reviews
Namzaric (Pro) Generic name: donepezil / memantine 8.8 6 reviews
Aricept ODT Generic name: donepezil 7.5 3 reviews
Razadyne ER Generic name: galantamine 10 2 reviews
Reminyl Generic name: galantamine 7.0 No reviews

What are natural acetylcholinesterase inhibitors?

Huperzine A (HupA), a novel alkaloid isolated from the Chinese herb Huperzia serrata, is a potent, highly specific and reversible inhibitor of acetylcholinesterase (AChE).

Does atropine inhibit acetylcholinesterase?

Atropine competitively inhibits the effects of cholinesterase inhibitors at muscarinic, but not nicotinic cholinergic receptors.

How does donepezil inhibit acetylcholinesterase?

Donepezil is a reversible acetylcholinesterase (AChE) inhibitor, which binds to the active site of the enzyme that degrades ACh and thus prevents the hydrolysis of it. This results in an increased concentration of ACh in the synapses available for neurotransmission.

Where can I get acetylcholinesterase?

Acetylcholinesterase is found in nerve tissue and red blood cells. Pseudocholinesterase is found primarily in the liver.

Which acetylcholinesterase inhibitors cross blood brain barrier?

Rivastigmine (Figure 3) is a carbamate inhibitor of AChE as well as BChE and it easily crosses the blood brain barrier.

Is neostigmine an acetylcholinesterase inhibitor?

As an AChE inhibitor, neostigmine reversibly inhibits AChE in the active site by carbamylation of the serine Fig. 4, at mechanism of action. Therefore, it improves cholinergic action by facilitating impulse transmission through neuromuscular junctions.

What happens if you inhibit acetylcholinesterase?

The inhibition of the enzyme leads to accumulation of ACh in the synaptic cleft resulting in over-stimulation of nicotinic and muscarinic ACh receptors and impeded neurotransmission. The typical symptoms of acute poisoning are agitation, muscle weakness, muscle fasciculations, miosis, hypersalivation, sweating.

How does donepezil bind to acetylcholinesterase?

As portrayed in the crystallographic structure, donepezil binds and blocks the substrate catalytic site of the enzyme in one unique binding mode by forming hydrogen bond and π-stacking interactions with F326, W317, and W117, respectively.

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