Does SOCS have an SH2 domain?
The Suppressors of Cytokine Signaling (SOCS) proteins use an SH2 domain to bind to components of certain cytokine signaling pathways to downregulate the signaling cascade.
What does SOCS 3 do?
SOCS3 regulates cytokine or hormone signaling usually preventing, but in some cases aggravating, a variety of diseases. A main role of SOCS3 results from its binding to both the JAK kinase and the cytokine receptor, which results in the inhibition of STAT3 activation.
What is SOCS in biochemistry?
SOCS (suppressor of cytokine signaling proteins) refers to a family of genes involved in inhibiting the JAK-STAT signaling pathway.
How is SOCS activated?
The expression of SOCS proteins can be induced by cytokine stimulation, and they serve to interfere with signalling not only from the inducing cytokine in a classic “negative-feedback” loop, but also regulate signalling downstream of other cytokines, a process known as “cross-talk”.
What is the role of SOCS pathway in inflammation?
SOCS proteins regulate cytokine signal transduction for maintaining immune functions but still contribute to the onset of immunological diseases and inflammation (Yoshimura et al., 2005). Therefore, modulating cytokine release holds promise for minimizing disease progression.
What are SOCS family?
Suppressor of cytokine signaling (SOCS) family is a group of cytokine-inducible negative regulators by inhibiting multiple signaling pathways, especially the JAK/STAT signaling pathway [11-13].
Which molecules can terminate cytokine receptor signaling?
JAK/STAT signaling is terminated by negative regulators including the suppressors of cytokine signaling (SOCSs), protein tyrosine phosphatases, and protein inhibitors of activated STAT.
What are the 5 cytokines?
Cytokines include Interleukins, Lymphokines, Monokines, Interferons (IFN), colony stimulating factors (CSF), Chemokines and a variety of other proteins.
What chromosome is STAT3 on?
| STAT3 | ||
|---|---|---|
| Location (UCSC) | Chr 17: 42.31 – 42.39 Mb | Chr 11: 100.78 – 100.83 Mb |
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