What is the role of CD4 receptors?
The CD4 receptor plays a crucial role in the immune system, especially during T cell activation in which it can fulfill an adhesion or signaling function and enhance sensitivity of T cells to antigens.
What is CD4 Ligand?
The coreceptor molecule, CD4, plays an integral part in T cell activation; it is involved in both extracellular Ag recognition and intracellular signaling. We wanted to examine the functional role of CD4 in the recognition of agonist and altered peptide ligands (APLs).
What are CD4 CD25 cells?
Abstract. CD4+ T cells naturally expressing CD25 molecules (natural T regulatory cells (Tregs)) have a role in maintaining self tolerance and in regulating responses to infectious agents, transplantation Ags, and tumor Ags.
What does CD45RO stand for?
Human CD45 is a transmembrane tyrosine phosphatase present on all cells of haematopoietic origin, except RBCs. They exist in different isoforms that are expressed on a restricted group of cell types designated as CD45R .
What is CD4 expression?
CD4 is a transmembrane glycoprotein of 55 kDa that is expressed as a single polypeptide chain on the surface of MHC class II-restricted T cells. CD4 is also expressed to a minor extent on macrophages, some monocytes, some DCs and Langerhans cells, some B cells, and brain microglial cells.
What is CD25 a marker for?
CD25 is a marker for regulatory CD4+ T cells, present in the spleen and lymph nodes of normal rats, that can transfer protection from diabetes. A, CD4+CD45RC− cells were enriched by negative selection with the Abs OX8, OX22, and OX32 and magnetic beads (Dynal; purity of depletion, >98%).
What is CD25 positive?
Stromal CD4/CD25 positive T-cells are a strong and independent prognostic factor in non-small cell lung cancer patients, especially with adenocarcinomas. Lung Cancer.
What does a CD4 count of 400 mean?
The normal range for a CD4 count in an HIV negative person is between 400 and 1,600. This will cover 19 out of every 20 people (95%). But 1 in 20 HIV negative people (5%) have a normal CD4 count that is either less than 400 or higher than 1600. HIV negative people outside this range are still very healthy.