What is the pKa of NaH?
The pKa of the conjugate acid of sodium hydride (NaH) is about 35, the pKa of sodium hydroxide (NaOH) is about 16, and the pKa of the conjugate acid of sodium bicarbonate (NaHCO_3) is about 6.4.
Is NaH Super base?
This alkali metal hydride is primarily used as a strong yet combustible base in organic synthesis. NaH is a saline (salt-like) hydride, composed of Na+ and H− ions, in contrast to molecular hydrides such as borane, methane, ammonia, and water….Sodium hydride.
| Identifiers | |
|---|---|
| show InChI | |
| show SMILES | |
| Properties | |
| Chemical formula | NaH |
What is the pKa of CH3NH3Cl?
10.6
The pKa of methylamine [CH3NH3] is given as 10.6. This means that a salt of methylamine, such as CH3NH3Cl–, has an acidity constant Ka = 10-10.6, or 2.51 x 10-11.
Is pyridine a pKa?
Pyridine
| Names | |
|---|---|
| log P | 0.73 |
| Vapor pressure | 16 mmHg (20 °C) |
| Acidity (pKa) | 5.23 (pyridinium) |
| Conjugate acid | Pyridinium |
Is LDA or LiTMP more basic?
LiTMP is not simply a more expensive equivalent of LDA. LiTMP-mediated metalations have a greater driving force7,8 and disproportionately higher metalation rates, both of which may stem from high steric demands that inhibit stabilizing aggregation—a form of ground-state destabilization.
Does NaH Deprotonate?
The purpose of NaH [a strong base] is to deprotonate the alcohol (forming H2 in the process), making it into a nucleophilic alkoxide ion, which then performs a substitution reaction [ SN2 mechanism]. Remember – the conjugate base is always a better nucleophile.
Is NaH or NaOH stronger base?
Yes, NaH is a stronger base than NaOH. NaH is better at deprotonation when compared to NaOH.
What is the pKa of CH3NH3+?
The pKa of CH3NH3+ is 10.6.
What are the values of pKa for amino acids?
pKa and pI values of amino acids Amino acid 3-letter code 1-letter code pKa Cα-COOH pKa Cα-NH 3 + pKa side chain Isoelectric point (pI) Alanine Ala A 2.34 9.69 – 6.02 Arginine Arg R 2.17 9.04 12.48 10.76 Asparagine Asn N 2.02 8.80 – 5.41 Aspartic acid Asp D 2.09 9.82 3.86 2.98 Cysteine Cys C 1.71 10.78 8.33 5.02
What is the pKa of ammonium and nitrogen?
Compare the pKa’s. The pKa of the acid is near 5, and the pKa of the ammonium is near 9. The ammonium holds the proton more tightly than does the acid. The proton stays on the nitrogen. Amino acids are zwitterionic.
What is the pKa of carboxylic acid?
One is an amine, or a tetrahedral nitrogen attached to a carbon. The other is a carboxylic acid, which is a carbon that is double bonded to an oxygen and also attached to an OH or hydroxyl group. We have seen that carboxylic acids are moderately acidic. Most of them have pKa’s of 3 to 5.
What is the pKa of H2O?
Note; The pKavaluesassociated withbases is normally meant to refer to the true pKa’s of their conjugateacids; i.e., pKaassociated withHO-is 15.7, which is the pKaof H2O. This is often sloppily used byorganic chemists, and can lead to confusion, especially with amines.