What is the life expectancy of Waardenburg syndrome?
Waardenburg syndrome shouldn’t affect your life expectancy. It usually doesn’t accompany any other complications, other than inner-ear deafness or Hirschsprung’s disease, which affects the colon. The physical features affected by the condition will remain with you for life.
What are the four types of Waardenburg syndrome?
Abstract. Waardenburg syndrome (WS) is an auditory-pigmentary syndrome caused by a deficiency of melanocytes and other neural crest-derived cells. Depending on a variety of symptoms associated with the auditory-pigmentary symptoms, WS is classified into four types: WS type 1 (WS1), WS2, WS3, and WS4.
What are the symptoms of Waardenburg syndrome?
Symptoms may include:
- Cleft lip (rare)
- Deafness (more common in type II disease)
- Extremely pale blue eyes or eye colors that don’t match (heterochromia)
- Pale color skin, hair, and eyes (partial albinism)
- Difficulty completely straightening joints.
- Possible slight decrease in intellectual function.
Is Waardenburg syndrome caused by inbreeding?
No. Waardenburg syndrome type 1 is an autosomal dominant condition. Consanguinity refers to the genetic relatedness between individuals descended from at least one common ancestor.
How is Waardenburg syndrome inherited?
Inheritance. Waardenburg syndrome is usually inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to cause the disorder. In most cases, an affected person has one parent with the condition.
Does Paris Jackson have Waardenburg syndrome?
Although Baker doesn’t name the condition, she does note that it doesn’t impact Jackson’s eyesight. With that in mind, Jackson may likely have Waardenburg syndrome (WS). The syndrome is a genetic condition that can impact the coloring or pigmentation of your eyes.
How do you get Waardenburg syndrome?
Waardenburg syndrome is most often inherited as an autosomal dominant trait. This means only one parent has to pass on the faulty gene for a child to be affected.
How common is Alagille syndrome?
The estimated prevalence of Alagille syndrome is 1 in 70,000 newborns. This figure is based on diagnoses of liver disease in infants, and may be an underestimation because some people with Alagille syndrome do not develop liver disease during infancy.