What is the function of MCP?
Monocyte chemoattractant protein-1 (MCP-1/CCL2) is one of the key chemokines that regulate migration and infiltration of monocytes/macrophages. Both CCL2 and its receptor CCR2 have been demonstrated to be induced and involved in various diseases.
What produces MCP-1?
MCP-1 can be produced by a variety of cell types, such as macrophages, neutrophils, fibroblasts, endothelial cells, and epithelial cells.
Does MCP-1 cause inflammation?
In summary, our data suggest that MCP-1 may be a necessary component of the inflammatory response required for adipose tissue protection, remodeling, and healthy expansion in the FVB/N strain in response to HFD feedings.
What is CCL2?
CCL2/CCR2 signaling is best known for its role in regulating macrophage recruitment and polarization during inflammation. CCL2 regulates cellular adhesion and chemotaxis of macrophages through activation of β1 integrins and p38MAPK signaling pathways (Ashida, Arai, Yamasaki, & Kita, 2001).
What is MCP in blood?
However, whether blood PTX3 level can be used as an indicator of clinical RA disease activity is unknown. Another new mediator of inflammation, monocyte chemotactic protein-1 (MCP-1), is chemotactic for monocytes, basophils, T cells, and mast cells [19].
What is MCP lab?
Molecular & Cardiovascular Physiology Laboratory (MCP Lab)
What is MCP cytokine?
Chemokines (chemotactic cytokines) are small heparin-binding proteins that constitute a large family of peptides (60–100 amino acids) structurally related to cytokines, whose main function is to regulate cell trafficking.
What is MCP in inflammation?
BACKGROUND: Monocyte chemoattractant protein 1 (MCP-1) is known to be an important chemokine for macrophage. recruitment. Thus, targeting MCP-1 may prevent the perturbations associated with macrophage-induced inflammation in adipose. tissue.
Are chemokines cytokines?
Chemokines are a family of small cytokines, or signaling proteins secreted by cells. Their name is derived from their ability to induce directed chemotaxis in nearby responsive cells; they are chemotactic cytokines.
Is MCP-1 proinflammatory cytokine?
The circulating levels of MCP-1 are increased in obese subjects [29]. MCP-1 plays a clear proinflammatory role in skeletal muscle, since specific muscular overexpression of MCP-1 in mice increases the expression of IL-1β and the macrophage markers F4/80 and CD68 in the gastrocnemius muscle [42].