What is herb drug interaction?
Any pharmacological modification caused by herbal substances to another prescription medication (diagnostic, therapeutic or other action of a drug) in or on the body. An herb might increases or decreases the effects of co-administered drugs. Consequences can be beneficial, undesirable or harmful effects.
Which route of administration is most likely to cause toxic effects?
Intravenous administration bypasses absorption barriers. It is potentially the most hazardous route of administration as a high concentration of drug is delivered to organs as rapidly as the rate of injection, which may elicit toxic effects.
When determining the half life of a drug What must be taken into account?
Related Stories. There are two factors that affect the elimination half-life of a drug, which include its clearance and volume of distribution. The clearance of the drug (CL) refers to the rate at which the body eliminates the drug from the body.
What herbal supplements should not be taken together?
Some of the most problematic substances are herbal products that are widely known, such as St. John’s wort and Ginkgo biloba. According to the report, herbals such as sage, flax seed, cranberry, goji berry, chamomile, and green tea can interact with some cardiovascular drugs and cause bleeding.
How long do herbal supplements stay in your system?
They are similar to pharmaceuticals in that they are medicine, but the body processes them the same way it processes food. They stay in the system for three to four hours at most, so they require a longer-term regimen.
Which drug has a high first pass effect?
Notable drugs that experience a significant first-pass effect are imipramine, morphine, propranolol, buprenorphine, diazepam, midazolam, pethidine, tetrahydrocannabinol (THC), ethanol (drinking alcohol), cimetidine, lidocaine, and chlorpromazine.
Which are the two most important sites for drug elimination?
As can be seen in the preceding equation, the main contributors to drug excretion are the kidneys and the liver. Water-soluble compounds are excreted primarily by the kidneys, while larger, more hydrophobic compounds are the responsibility of the liver.
What drug has the shortest half-life?
This class of drugs has evolved from a drug such as amlodipine, with a long duration of action related to prolonged plasma half-life, to lercanidipine, which has the shortest plasma half-life relative to its intrinsically long duration of action.