What causes cutis aplasia?

What causes cutis aplasia?

Causes. Nonsyndromic aplasia cutis congenita can have different causes, and often the cause is unknown. Because the condition is sometimes found in multiple members of a family, it is thought to have a genetic component; however, the genetic factors are not fully understood.

Is aplasia cutis life threatening?

Aplasia cutis congenita is a rare congenital anomaly characterized by the absence of a patch of skin since birth. It may lead to life threatening complications at times.

What does cutis aplasia look like?

The typical lesion is small (0.5cm10cm), well circumscribed, with different aspects: circular, oval, linear or stellate, membranous (membranelike surface) or non-membranous (irregular and larger). Aplasia cutis may be associated with defects of the underlying skull, especially when the skin lesion is larger than 10cm.

What causes Nonsyndromic aplasia cutis congenita?

In some cases, nonsyndromic aplasia cutis congenita is caused by exposure to a drug called methimazole before birth. This medication is given to treat an overactive thyroid gland. Babies whose mothers take this medication during pregnancy are at increased risk of having the condition.

What aplasia means?

Aplasia is a condition in which an organ, limb, or other body part does not develop. In most cases, aplasia is obvious at birth.

Is aplasia and agenesis the same?

CONGENITAL BRONCHOPULMONARY MALFORMATIONS Pulmonary agenesis is the complete failure of both airway and parenchymal development. Pulmonary aplasia is used to describe the incomplete development of lung parenchyma supplied by a rudimentary bronchus.

What is aplasia mean?

Aplasia (/əˈpleɪʒə/ ( listen); from Greek a, “not”, “no” + plasis, “formation”) is a birth defect where an organ or tissue is wholly or largely absent. It is caused by a defect in a developmental process. Aplastic anemia is the failure of the body to produce blood cells.

What is aplasia cutis congenita?

Aplasia Cutis Congenita is a rare disorder with a complicated pattern of inheritance. Babies are born with the absence of certain layer (s) of skin, most often on the scalp, but also on the trunk, and/or arms and legs. The affected area is typically covered with a thin, transparent membrane.

What is collapse section nonsyndromic aplasia cutis congenita?

Collapse Section Nonsyndromic aplasia cutis congenita is a condition in which babies are born with localized areas of missing skin (lesions). These areas resemble ulcers or open wounds, although they are sometimes already healed at birth.

What are the signs and symptoms of nonsyndromic aplasia cutis congenita?

Skin lesions are typically the only feature of nonsyndromic aplasia cutis congenita, although other skin problems and abnormalities of the bones and other tissues occur rarely. However, the characteristic skin lesions can occur as one of many symptoms in other conditions, including Johanson-Blizzard syndrome and Adams-Oliver syndrome.

What are the complications of aplasia cutis congenita (AC)?

Major complications of aplasia cutis congenita are rare, but can include hemorrhage, secondary local infection, meningitis, or sagittal sinus thrombosis. Larger affected areas associated with underlying bony defects can cause death due to central nervous systeminfection, or hemorrhage from the sagittal sinus.

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